SLC39A14, solute carrier family 39 member 14

SLC39A14, solute carrier family 39 member 14

• This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

• Gene Synonyms (metal cation symporter ZIP14, LIV-1 subfamily of ZIP zinc transporter 4, Zinc transporter ZIP14, Zrt-, Irt-like protein 14, solute carrier family 39 (metal ion transporter), member 14, solute carrier family 39 (zinc transporter), member 14, zrt- and Irt-like protein 14, HCIN, HMNDYT2, LZT-Hs4, NET34, ZIP14, cig19,)
• NCBI Gene ID: 23516
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z534
  UNIPROT ID#>>Q15043
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 39 member 14 interacts with:

• acylglycerol kinase
  leucine zipper tumor suppressor 2
  septin 3
  solute carrier family 15 member 3
  stimulator of interferon response cGAMP interactor 1
  transmembrane protein 17
  transmembrane protein 216
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.