RUFY3, RUN and FYVE domain containing 3

RUFY3, RUN and FYVE domain containing 3

• This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

• Gene Synonyms (RIPX, SINGAR1, ZFYVE30, protein RUFY3, rap2 interacting protein x, single axon-regulated protein, single axon-related 1,)
• NCBI Gene ID: 22902
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDD7
  UNIPROT ID#>>B4DKC2
  UNIPROT ID#>>Q7L099
  UNIPROT ID#>>B4DG59
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RUN and FYVE domain containing 3 interacts with:

• ABI family member 3
  ADAM metallopeptidase with thrombospondin type 1 motif 12
  ankyrin repeat and SOCS box containing 8
  chitinase acidic
  CTTNBP2 N-terminal like
  DDB1 and CUL4 associated factor 15
  glucosidase II alpha subunit
  glycosyltransferase 1 domain containing 1
  RUN and FYVE domain containing 1
  RUN and FYVE domain containing 2
  tRNA methyltransferase 9B (putative)

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.