NLRP6, NLR family pyrin domain containing 6

NLRP6, NLR family pyrin domain containing 6

• The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

• Gene Synonyms (NACHT, LRR and PYD domains-containing protein 6, NACHT, leucine rich repeat and PYD containing 6, PYRIN-containing APAF1-like protein 5, angiotensin II/vasopressin receptor, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5,)
• NCBI Gene ID: 171389
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P59044
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NLR family pyrin domain containing 6 interacts with:

• TGF-beta activated kinase 1 (MAP3K7) binding protein 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.