CYP2A6, cytochrome P450 family 2 subfamily A member 6

CYP2A6, cytochrome P450 family 2 subfamily A member 6

• This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cytochrome P450 2A6, 1,4-cineole 2-exo-monooxygenase, coumarin 7-hydroxylase, cytochrome P450 IIA3, cytochrome P450(I), cytochrome P450, family 2, subfamily A, polypeptide 6, cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6, flavoprotein-linked monooxygenase, xenobiotic monooxygenase, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB,)
• NCBI Gene ID: 1548
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P11509
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome P450 family 2 subfamily A member 6 interacts with:

• cytochrome P450 family 2 subfamily A member 7
  cytochrome p450 oxidoreductase
  Rab acceptor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.