ARHGAP42, Rho GTPase activating protein 42

ARHGAP42, Rho GTPase activating protein 42

• This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]

• Gene Synonyms (AD031, GRAF3, TMEM133, rho GTPase-activating protein 42, rho-type GTPase-activating protein 42, transmembrane protein 133,)
• NCBI Gene ID: 143872
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A6NI28
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GTPase activating protein 42 interacts with:

• DENN domain containing 2C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.