Fkbp1a, FK506 binding protein 1a

Fkbp1a, FK506 binding protein 1a

• This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

• (No alternate names found)
• NCBI Gene ID: 14225
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>P26883
  UNIPROT ID#>>Q1JUQ7
  UNIPROT ID#>>Q1JUQ8
  UNIPROT ID#>>Q3UKJ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FK506 binding protein 1a interacts with:

• dihydroorotate dehydrogenase
  transforming growth factor, beta receptor I
  transient receptor potential cation channel, subfamily V, member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.