CRHR1, corticotropin releasing hormone receptor 1

CRHR1, corticotropin releasing hormone receptor 1

• This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]

• Gene Synonyms (corticotropin-releasing factor receptor 1, CRH receptor 1, corticotropin-releasing factor type 1 receptor, seven transmembrane helix receptor, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L,)
• NCBI Gene ID: 1394
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3TIK8
  UNIPROT ID#>>P34998
  UNIPROT ID#>>G3CIS4
  UNIPROT ID#>>K9J956
  UNIPROT ID#>>B3SXS2
  UNIPROT ID#>>A0A024R9X9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

corticotropin releasing hormone receptor 1 interacts with:

• discs large MAGUK scaffold protein 1
  discs large MAGUK scaffold protein 1
  discs large MAGUK scaffold protein 4
  G protein subunit alpha i1
  G protein subunit alpha o1
  G protein subunit alpha q
  GNAS complex locus
  golgi associated PDZ and coiled-coil motif containing
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  membrane associated guanylate kinase, WW and PDZ domain containing 2
  membrane associated guanylate kinase, WW and PDZ domain containing 3
  multiple PDZ domain crumbs cell polarity complex component
  PDZ domain containing 1
  protein tyrosine phosphatase non-receptor type 13
  SRSF protein kinase 1
  urocortin
  urocortin 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.