CPOX, coproporphyrinogen oxidase

CPOX, coproporphyrinogen oxidase

• The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]

• Gene Synonyms (oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial, coprogen oxidase, coproporphyrinogenase, homozygous coproporphyria, COX, CPO, CPX, HARPO, HCP,)
• NCBI Gene ID: 1371
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P36551
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coproporphyrinogen oxidase interacts with:

• apoptosis inducing factor mitochondria associated 1
  cullin 3
  cytochrome c oxidase assembly factor COX14
  dual specificity phosphatase 13
  ELAV like RNA binding protein 1
  EYA transcriptional coactivator and phosphatase 4
  ferredoxin 1
  ferredoxin 2
  fumarate hydratase
  glycine cleavage system protein H
  minichromosome maintenance complex component 2
  NADH:ubiquinone oxidoreductase subunit AB1
  nudix hydrolase 9
  plasminogen receptor with a C-terminal lysine
  pleckstrin homology domain containing A4
  RecQ like helicase 4
  serine/threonine/tyrosine interacting protein
  sideroflexin 1
  superoxide dismutase 1
  synthesis of cytochrome C oxidase 1
  transcription factor 4
  triosephosphate isomerase 1
  tRNA nucleotidyl transferase 1
  twinkle mtDNA helicase
  tyrosyl-tRNA synthetase 1
  ubiquitin conjugating enzyme E2 G2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.