TMEM123, transmembrane protein 123

TMEM123, transmembrane protein 123

• This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

• Gene Synonyms (KCT3, PORIMIN, PORMIN, porimin, KCT-3, keratinocytes associated transmembrane protein 3, pro-oncosis receptor inducing membrane injury, serine/threonine-rich receptor,)
• NCBI Gene ID: 114908
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N131
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane protein 123 interacts with:

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