CHRNB4, cholinergic receptor nicotinic beta 4 subunit

CHRNB4, cholinergic receptor nicotinic beta 4 subunit

• This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

• Gene Synonyms (neuronal acetylcholine receptor subunit beta-4, acetylcholine receptor, nicotinic, beta 4 (neuronal), cholinergic receptor, nicotinic, beta 4 (neuronal), cholinergic receptor, nicotinic, beta polypeptide 4, neuronal nicotinic receptor beta 4 subunit,)
• NCBI Gene ID: 1143
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30926
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cholinergic receptor nicotinic beta 4 subunit interacts with:

• mesenchyme homeobox 2
  ring finger protein 123
  tripartite motif containing 25
  ubiquilin 1
  ubiquilin 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.