KLF12, Kruppel like factor 12

KLF12, Kruppel like factor 12

• Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (Krueppel-like factor 12, AP-2 repressor, AP-2rep transcription factor, KLF12 zinc finger transcriptional repressor, transcriptional repressor AP-2rep, AP-2rep, AP2REP, HSPC122,)
• NCBI Gene ID: 11278
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WWI3
  UNIPROT ID#>>Q9Y4X4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Kruppel like factor 12 interacts with:

• DNA methyltransferase 3 like
  indoleamine 2,3-dioxygenase 2
  THAP domain containing 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.