KATNA1, katanin catalytic subunit A1

KATNA1, katanin catalytic subunit A1

• Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

• Gene Synonyms (katanin p60 ATPase-containing subunit A1, katanin p60 (ATPase containing) subunit A 1, katanin p60 subunit A1, p60 katanin,)
• NCBI Gene ID: 11104
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K7S5
  UNIPROT ID#>>O75449
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

katanin catalytic subunit A1 interacts with:

• ankyrin repeat and SOCS box containing 3
  ariadne RBR E3 ubiquitin protein ligase 1
  coiled-coil domain containing 88C
  dynein cytoplasmic 1 heavy chain 1
  enolase-phosphatase 1
  golgi transport 1B
  inositol polyphosphate-5-phosphatase K
  katanin p80 (WD40-containing) subunit B 1
  katanin regulatory subunit B1 like 1
  kelch like family member 42
  lacritin
  NCK associated protein 5 like
  nudE neurodevelopment protein 1 like 1
  nudE neurodevelopment protein 1 like 1
  regulator of telomere elongation helicase 1
  Rho GTPase activating protein 39
  SH3 domain containing kinase binding protein 1
  solute carrier family 30 member 7
  SRP receptor subunit beta
  SSX family member 2 interacting protein
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 47

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.