PRG4, proteoglycan 4

PRG4, proteoglycan 4

• The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

• Gene Synonyms (proteoglycan 4, articular superficial zone protein, hemangiopoietin, lubricin, megakaryocyte stimulating factor, superficial zone proteoglycan, CACP, HAPO, JCAP, MSF, SZP,)
• NCBI Gene ID: 10216
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0U1RR20
  UNIPROT ID#>>Q92954
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteoglycan 4 interacts with:

• ring finger protein 123

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.