ITGAX, integrin subunit alpha X

ITGAX, integrin subunit alpha X

• This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

• Gene Synonyms (CD11C, SLEB6, integrin alpha-X, CD11 antigen-like family member C, complement component 3 receptor 4 subunit, integrin alpha X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), integrin, alpha X (complement component 3 receptor 4 subunit), leu M5, alpha subunit, leukocyte adhesion glycoprotein p150,95 alpha chain, leukocyte adhesion receptor p150,95, leukocyte surface antigen p150,95, alpha subunit, myeloid membrane antigen, alpha subunit, p150 95 integrin alpha chain,)
• NCBI Gene ID: 3687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20702
  UNIPROT ID#>>H3BN02
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit alpha X interacts with:

• integrin subunit beta 2
  junctional adhesion molecule 3
  MIA SH3 domain ER export factor 3

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