Alterations in Gene Expression

The development of cancer is driven by changes in the patterns of gene expression. Disruption of normal expression levels can lead to under- or overexpression of tumor suppressors and oncogenes, leading to tumorigenesis. Studying regulatory mechanisms and expression changes can help us better understand cancer biology and identify potential therapeutic targets.

microRNA

microRNAs (miRNAs) play an important role in regulating thousands of human genes, including oncogenes and tumor suppressor genes. Gene expression studies could help us understand how miRNA dysregulation could lead to the development of many types of cancer.

The Role of miRNA in Cancer

Read about recent research on miRNA regulation of gene expression.

miRNA Analysis Paired with a Novel Cell Health Assay

This webinar describes an approach to using novel assays to monitor cell health and purifying total RNA (including miRNAs) from the same cells.

miRNA Purification from Tissue

Purify miRNA that's ready for challenging downstream applications.

Working with RNA

The transcriptome reflects the gene activity within a specific cell or tissue type. We can use this data to draw conclusions about normal and disrupted behavior.

RNA Quality Assessment

Read more about determining the quality of RNA samples.

RNA Purification from FFPE Samples

FFPE is the most common sample type for analyzing tumor tissue.

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