SLC12A1, solute carrier family 12 member 1

SLC12A1, solute carrier family 12 member 1

• This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]

• Gene Synonyms (solute carrier family 12 member 1, NKCC2A variant A, Na-K-2Cl cotransporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, kidney-specific Na-K-Cl symporter, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1, BSC1, NKCC2,)
• NCBI Gene ID: 6557
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IUN5
  UNIPROT ID#>>Q13621
  UNIPROT ID#>>B4DPF4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 12 member 1 interacts with:

• oxidative stress responsive kinase 1
  serine/threonine kinase 39

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.