DNASE2B, deoxyribonuclease 2 beta

DNASE2B, deoxyribonuclease 2 beta

• The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (deoxyribonuclease-2-beta, DNase II beta, DNase II-like acid DNase, DNase2-like acid DNase, deoxyribonuclease II beta, endonuclease DLAD, lysosomal DNase II, DLAD,)
• NCBI Gene ID: 58511
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WZ79
  UNIPROT ID#>>Q66K39
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

deoxyribonuclease 2 beta interacts with:

• adhesion G protein-coupled receptor V1
  FRAS1 related extracellular matrix 2
  fucosyltransferase 11
  spermatogenesis associated 5
  tectonic family member 1
  torsin family 3 member A
  transmembrane O-mannosyltransferase targeting cadherins 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.