ATP6AP1, ATPase H+ transporting accessory protein 1

ATP6AP1, ATPase H+ transporting accessory protein 1

• This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

• Gene Synonyms (V-type proton ATPase subunit S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1, ATPase, H+ transporting, lysosomal accessory protein 1, ATPase, H+ transporting, lysosomal interacting protein 1, H-ATPase subunit, V-ATPase Ac45 subunit, V-ATPase S1 accessory protein, V-ATPase subunit S1, epididymis secretory sperm binding protein, protein XAP-3, vacuolar proton pump subunit S1, 16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3,)
• NCBI Gene ID: 537
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0C4DGX8
  UNIPROT ID#>>Q15904
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATPase H+ transporting accessory protein 1 interacts with:

• ariadne RBR E3 ubiquitin protein ligase 1
  ATPase H+ transporting accessory protein 2
  ATPase H+ transporting V0 subunit a2
  ATPase H+ transporting V0 subunit d1
  basic transcription factor 3
  bone morphogenetic protein receptor, type 1A
  calnexin
  carbonic anhydrase 9
  charged multivesicular body protein 4B
  CTD nuclear envelope phosphatase 1
  cytochrome b5 reductase 3
  drebrin 1
  ER membrane protein complex subunit 1
  ER membrane protein complex subunit 2
  ER membrane protein complex subunit 4
  ER membrane protein complex subunit 6
  ER membrane protein complex subunit 7
  erb-b2 receptor tyrosine kinase 2
  EvC ciliary complex subunit 2
  farnesyl diphosphate synthase
  F-box protein 6
  general transcription factor IIIC subunit 3
  glypican 1
  golgi transport 1B
  growth factor independent 1B transcriptional repressor
  hemoglobin subunit alpha 1
  hemoglobin subunit alpha 2
  heterogeneous nuclear ribonucleoprotein A/B
  integrin alpha FG-GAP repeat containing 1
  KIAA2013
  membrane bound transcription factor peptidase, site 2
  microsomal glutathione S-transferase 1
  mitogen-activated protein kinase 6
  Mov10 RISC complex RNA helicase
  myelin expression factor 2
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 1 group I member 2
  nuclear RNA export factor 1
  OTU deubiquitinase with linear linkage specificity like
  potassium channel, subfamily K, member 1
  proteasome 26S subunit, non-ATPase 12
  protein interacting with PRKCA 1
  protein tyrosine phosphatase receptor type O
  RAB7A, member RAS oncogene family
  ras homolog family member U
  ring finger protein 4
  RNA binding motif protein 25
  SCY1 like pseudokinase 1
  spastin
  synoviolin 1
  tectonic family member 2
  tectonic family member 3
  transmembrane p24 trafficking protein 2
  transmembrane protein 17
  transmembrane protein 216
  transmembrane protein 67
  vacuolar protein sorting 72 homolog
  voltage dependent anion channel 3
  WD repeat domain 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.