ARNTL, aryl hydrocarbon receptor nuclear translocator like

ARNTL, aryl hydrocarbon receptor nuclear translocator like

• The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

• Gene Synonyms (aryl hydrocarbon receptor nuclear translocator-like protein 1, ARNT-like protein 1, brain and muscle, PAS domain containing 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, basic helix-loop-helix family member e5, basic-helix-loop-helix-PAS orphan MOP3, basic-helix-loop-helix-PAS protein MOP3, brain and muscle ARNT-like 1, class E basic helix-loop-helix protein 5, member of PAS protein 3, member of PAS superfamily 3, testis tissue sperm-binding protein Li 50e, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5,)
• NCBI Gene ID: 406
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VKD3
  UNIPROT ID#>>O00327
  UNIPROT ID#>>B2RCL8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aryl hydrocarbon receptor nuclear translocator like interacts with:

• antizyme inhibitor 1
  aryl hydrocarbon receptor nuclear translocator like 2
  basal cell adhesion molecule (Lutheran blood group)
  basic helix-loop-helix family member e40
  casein kinase 1 epsilon
  casein kinase 2 alpha 1
  casein kinase 2 beta
  caveolae associated protein 1
  clock circadian regulator
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 93
  COP9 signalosome subunit 6
  CREB binding protein
  CREB binding protein
  cryptochrome 1 (photolyase-like)
  cryptochrome 2 (photolyase-like)
  cryptochrome circadian regulator 1
  cryptochrome circadian regulator 2
  cullin 1
  cullin associated and neddylation dissociated 1
  DAZ interacting zinc finger protein 3
  dehydrogenase E1 and transketolase domain containing 1
  dual specificity tyrosine phosphorylation regulated kinase 1B
  E1A binding protein p300
  endothelial PAS domain protein 1
  GIT ArfGAP 2
  golgin A5
  GRIP1 associated protein 1
  H4 clustered histone 1
  HAUS augmin like complex subunit 6
  heat shock protein 90 alpha family class A member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  high mobility group 20A
  HLF transcription factor, PAR bZIP family member
  hypoxia inducible factor 1 subunit alpha
  Jun proto-oncogene, AP-1 transcription factor subunit
  leucine rich repeat and fibronectin type III domain containing 4
  lysine acetyltransferase 2B
  lysine demethylase 1A
  MYC associated factor X
  NCK associated protein 5 like
  neuronal PAS domain protein 2
  neuronal PAS domain protein 4
  NUF2 component of NDC80 kinetochore complex
  Opa interacting protein 5
  period circadian regulator 3
  PHD finger protein 21A
  pleckstrin homology like domain family B member 3
  proteasome 20S subunit beta 1
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 2
  protein kinase N3
  protein phosphatase 1 catalytic subunit alpha
  RAB GTPase activating protein 1 like
  RAB guanine nucleotide exchange factor 1
  RAR related orphan receptor C
  ras homolog family member U
  regulation of nuclear pre-mRNA domain containing 1A
  REST corepressor 1
  retinoic acid receptor alpha
  retinoid X receptor alpha
  sirtuin 1
  TBL1X receptor 1
  TCF3 fusion partner
  THAP domain containing 11
  TNF receptor associated factor 2
  trafficking protein particle complex 12
  transducin beta like 3
  tuftelin 1
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L5
  ubiquitin like modifier activating enzyme 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 38
  VPS50 subunit of EARP/GARPII complex
  VPS51 subunit of GARP complex
  VPS53 subunit of GARP complex
  WD repeat domain 5
  YEATS domain containing 4
  zinc finger MYND-type containing 12
  zinc finger protein 174
  zinc finger protein 207
  zinc finger protein 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.