ARG2, arginase 2

ARG2, arginase 2

• Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (arginase-2, mitochondrial, L-arginine amidinohydrolase, L-arginine ureahydrolase, arginase II, arginase, type II, kidney arginase, kidney-type arginase, non-hepatic arginase, nonhepatic arginase, type II arginase,)
• NCBI Gene ID: 384
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78540
  UNIPROT ID#>>A0A024R6A0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

arginase 2 interacts with:

• BAG cochaperone 5
  carnitine palmitoyltransferase 2
  matrilin 4
  serine/threonine kinase 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.