HYAL1, hyaluronidase 1

HYAL1, hyaluronidase 1

• This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (hyaluronidase-1, hyaluronoglucosaminidase 1, luCa-1, lung carcinoma protein 1, plasma hyaluronidase, tumor suppressor LUCA-1, HYAL-1, LUCA1, MPS9, NAT6,)
• NCBI Gene ID: 3373
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KUI5
  UNIPROT ID#>>Q12794
  UNIPROT ID#>>A0A024R2X3
  UNIPROT ID#>>A0A0S2Z3Q0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hyaluronidase 1 interacts with:

• kelch-like 21
  ring finger protein 123
  transient receptor potential cation channel subfamily C member 6
  tubulin alpha 1b
  tubulin alpha 4a
  UBA domain containing 1
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin protein ligase E3 component n-recognin 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.