HLA-DQA2, major histocompatibility complex, class II, DQ alpha 2

HLA-DQA2, major histocompatibility complex, class II, DQ alpha 2

• This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

• Gene Synonyms (HLA class II histocompatibility antigen, DQ alpha 2 chain, DC-1 alpha chain, DX alpha chain, HLA class II histocompatibility antigen, DQ alpha 1 chain, HLA class II histocompatibility antigen, DQ(6) alpha chain, MHC class II DQA1, MHC class II DQA2, MHC class II antigen, DC-alpha, DX-ALPHA, HLA-DCA, HLA-DXA, HLADQA2,)
• NCBI Gene ID: 3118
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P01906
  UNIPROT ID#>>Q76NI6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

major histocompatibility complex, class II, DQ alpha 2 interacts with:

• insulin
  LHFPL tetraspan subfamily member 5
  major histocompatibility complex, class II, DQ beta 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.