GSTA2, glutathione S-transferase alpha 2

GSTA2, glutathione S-transferase alpha 2

• Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (glutathione S-transferase A2, GST HA subunit 2, GST class-alpha member 2, GST-gamma, S-(hydroxyalkyl)glutathione lyase A2, glutathione S-alkyltransferase A2, glutathione S-aralkyltransferase A2, glutathione S-aryltransferase A2, liver GST2, testis tissue sperm-binding protein Li 59n, GST2, GSTA2-2, GTA2, GTH2,)
• NCBI Gene ID: 2939
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VKE2
  UNIPROT ID#>>A8K987
  UNIPROT ID#>>P09210
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutathione S-transferase alpha 2 interacts with:

• autophagy related 4C cysteine peptidase
  glutathione S-transferase alpha 3
  glutathione S-transferase alpha 4
  glutathione S-transferase alpha 5
  nucleolar and spindle associated protein 1

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