GALT, galactose-1-phosphate uridylyltransferase

GALT, galactose-1-phosphate uridylyltransferase

• Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

• Gene Synonyms (galactose-1-phosphate uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase, gal-1-P uridylyltransferase, galactose-1-phosphate uridyl transferase,)
• NCBI Gene ID: 2592
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07902
  UNIPROT ID#>>B2RAT6
  UNIPROT ID#>>A0A0S2Z3Y7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

galactose-1-phosphate uridylyltransferase interacts with:

• actin related protein 2/3 complex subunit 3
  GrpE like 1, mitochondrial
  keratin associated protein 6-2
  major histocompatibility complex, class II, DQ alpha 1
  nuclear receptor binding factor 2
  thyroid hormone receptor interactor 13
  transmembrane p24 trafficking protein 9
  tyrosine kinase non receptor 2
  ubiquitin domain containing 2
  VAC14 component of PIKFYVE complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.