- Gene Overview
- Interaction Network
- Sequence Verification
CR1, complement C3b/C4b receptor 1 (Knops blood group)
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This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
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Gene Synonyms (complement receptor type 1, C3-binding protein, C3b/C4b receptor, CD35 antigen, Knops blood group antigen, complement component (3b/4b) receptor 1 (Knops blood group), complement receptor 1, C3BR, C4BR, CD35, KN,)
- NCBI Gene ID:
1378
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>E9PDY4
UNIPROT ID#>>P17927
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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complement C3b/C4b receptor 1 (Knops blood group) interacts with:
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