CLDN4, claudin 4

CLDN4, claudin 4

• The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

• Gene Synonyms (claudin-4, CPE-receptor, Clostridium perfringens enterotoxin receptor 1, Williams-Beuren syndrome chromosomal region 8 protein, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R,)
• NCBI Gene ID: 1364
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14493
  UNIPROT ID#>>Q75L80
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

claudin 4 interacts with:

• ADP ribosylation factor like GTPase 13B
  C-type lectin domain containing 14A
  EPH receptor A2
  estrogen receptor 2
  family with sequence similarity 209 member A
  free fatty acid receptor 2
  gap junction protein alpha 8
  golgi membrane protein 1
  hydroxysteroid 17-beta dehydrogenase 13
  intercellular adhesion molecule 3
  major facilitator superfamily domain containing 14B
  sex hormone binding globulin
  synaptotagmin 2
  tight junction protein 1
  translocator protein 2
  transmembrane protein 237
  transmembrane protein 52B
  tripartite motif containing 59
  WNK lysine deficient protein kinase 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.