CPB2, carboxypeptidase B2

CPB2, carboxypeptidase B2

• Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

• Gene Synonyms (carboxypeptidase B2, carboxypeptidase B-like protein, carboxypeptidase B2 (plasma), carboxypeptidase B2 (plasma, carboxypeptidase U), carboxypeptidase R, thrombin-activable fibrinolysis inhibitor, thrombin-activatable fibrinolysis inhibitor, CPU, PCPB, TAFI,)
• NCBI Gene ID: 1361
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96IY4
  UNIPROT ID#>>A0A087WSY5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

carboxypeptidase B2 interacts with:

• coagulation factor II, thrombin
  fibronectin 1
  plasminogen
  PZP alpha-2-macroglobulin like
  tubulointerstitial nephritis antigen

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.