COL5A1, collagen type V alpha 1 chain

COL5A1, collagen type V alpha 1 chain

• This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

• Gene Synonyms (collagen alpha-1(V) chain, collagen, type V, alpha 1, EDSC, EDSCL1,)
• NCBI Gene ID: 1289
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WXW9
  UNIPROT ID#>>A0A024R8E5
  UNIPROT ID#>>Q59EE7
  UNIPROT ID#>>P20908
  UNIPROT ID#>>B2ZZ86
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

collagen type V alpha 1 chain interacts with:

• actin, beta
  C1q and TNF related 2
  casein kinase 2 alpha 2
  collagen type V alpha 3 chain
  collagen type VIII alpha 2 chain
  decorin
  F-box and WD-40 domain protein 11
  galectin 3 binding protein
  heterogeneous nuclear ribonucleoprotein L
  insulin-like growth factor binding protein 7
  matrix metallopeptidase 2
  matrix metallopeptidase 9
  myelin associated glycoprotein
  platelet derived growth factor subunit A
  platelet derived growth factor subunit B
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  protein phosphatase 2, regulatory subunit A, alpha
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase, non-receptor type 2
  secreted protein acidic and cysteine rich
  serine protease 23
  sirtuin 7
  SMAD family member 3
  syndecan 3
  thrombospondin 1
  transglutaminase 2
  tripartite motif containing 25
  tubulin, alpha 3A
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.