IL18BP, interleukin 18 binding protein

IL18BP, interleukin 18 binding protein

• The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (interleukin-18-binding protein, MC51L-53L-54L homolog gene product, tadekinig-alfa, FVH, IL18BPa,)
• NCBI Gene ID: 10068
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95998
  UNIPROT ID#>>A0A024R5I1
  UNIPROT ID#>>A0A024R5G2
  UNIPROT ID#>>G3V1C5
  UNIPROT ID#>>A0A024R5M7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 18 binding protein interacts with:

• interleukin 37

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