CD70, CD70 molecule

CD70, CD70 molecule

• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD70 antigen, CD27 ligand, Ki-24 antigen, surface antigen CD70, tumor necrosis factor ligand 8A, tumor necrosis factor ligand superfamily member 7, CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A,)
• NCBI Gene ID: 970
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0U5JA32
  UNIPROT ID#>>P32970
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD70 molecule interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 5
  alanyl-tRNA synthetase 2, mitochondrial
  asparaginyl-tRNA synthetase 2, mitochondrial
  atlastin GTPase 3
  ATR interacting protein
  choline phosphotransferase 1
  coenzyme Q8B
  defective in cullin neddylation 1 domain containing 5
  DEP domain containing 1
  dymeclin
  ELAV like RNA binding protein 1
  ELOVL fatty acid elongase 4
  eukaryotic translation initiation factor 2B subunit gamma
  exocyst complex component 6
  exportin 4
  exportin 7
  FA complementation group G
  G protein nucleolar 3 like
  G protein-coupled receptor class C group 5 member B
  glomulin, FKBP associated protein
  glucoside xylosyltransferase 2
  glycerol kinase
  HEAT repeat containing 3
  huntingtin interacting protein 1 related
  HUS1 checkpoint clamp component
  importin 11
  integrator complex subunit 2
  integrator complex subunit 3
  integrator complex subunit 4
  integrator complex subunit 5
  interferon related developmental regulator 1
  lysine demethylase 8
  methyltransferase like 15
  midasin AAA ATPase 1
  mitogen-activated protein kinase kinase 2
  mitogen-activated protein kinase kinase 3
  mitoguardin 1
  NOP9 nucleolar protein
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 2 group F member 1
  nuclear receptor subfamily 2 group F member 2
  nucleolar protein 11
  nucleoporin 107
  nucleoporin 160
  nucleoporin 85
  nucleoporin 98 and 96 precursor
  origin recognition complex subunit 5
  PDS5 cohesin associated factor A
  PDS5 cohesin associated factor B
  phospholipase A2 activating protein
  protein phosphatase targeting COQ7
  pyridoxal dependent decarboxylase domain containing 1
  RAN binding protein 6
  ribosome binding factor A
  ring finger protein 4
  RUN and FYVE domain containing 1
  RUN and FYVE domain containing 2
  SEC14 like lipid binding 1
  secretory carrier membrane protein 1
  signal peptide peptidase like 2B
  solute carrier family 30 member 5
  solute carrier family 31 member 1
  stromal antigen 2
  TAM41 mitochondrial translocator assembly and maintenance homolog
  TBC1 domain family member 20
  TELO2 interacting protein 1
  timeless circadian regulator
  TNF receptor superfamily member 13B
  transcription factor B2, mitochondrial
  transforming growth factor beta regulator 4
  transportin 3
  tubulin beta 8 class VIII
  tweety family member 3
  ubiquitin specific peptidase 22
  ubiquitination factor E4A
  uridine-cytidine kinase 1 like 1
  UTP20 small subunit processome component

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.