KLF5, Kruppel like factor 5

KLF5, Kruppel like factor 5

• This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

• Gene Synonyms (Krueppel-like factor 5, (intestinal Kruppel-like factor, BTE-binding protein 2, GC box binding protein 2, Klf5C isoform, Kruppel-like factor 5 (intestinal), basic transcription element binding protein 2, colon krueppel-like factor, colon kruppel-like factor, epididymis secretory sperm binding protein, intestinal-enriched krueppel-like factor, intestinal-enriched kruppel-like factor, transcription factor BTEB2, BTEB2, CKLF, IKLF,)
• NCBI Gene ID: 688
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13887
  UNIPROT ID#>>Q5T6X2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Kruppel like factor 5 interacts with:

• acidic nuclear phosphoprotein 32 family member B
  actin related protein 5
  ataxin 3 like
  BRCA1 associated protein 1
  catenin beta 1
  CCAAT enhancer binding protein alpha
  CCAAT enhancer binding protein beta
  CCAAT enhancer binding protein gamma
  CREB binding protein
  cysteine and glycine rich protein 3
  E1A binding protein p300
  egl-9 family hypoxia inducible factor 3
  ELAV like RNA binding protein 1
  estrogen receptor 1
  estrogen receptor 2
  exportin 1
  F-box and WD repeat domain containing 7
  general transcription factor IIB
  general transcription factor IIE subunit 2
  general transcription factor IIF subunit 2
  glycogen synthase kinase 3 beta
  H4 clustered histone 1
  histone deacetylase 1
  histone deacetylase 2
  host cell factor C1
  Jun proto-oncogene, AP-1 transcription factor subunit
  N(alpha)-acetyltransferase 10, NatA catalytic subunit
  nuclear factor kappa B subunit 1
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  O-linked N-acetylglucosamine (GlcNAc) transferase
  peroxisome proliferator activated receptor gamma
  protein kinase C alpha
  protein kinase C delta
  retinoic acid receptor alpha
  retinoid X receptor alpha
  ribosome binding protein 1
  SET nuclear proto-oncogene
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 2
  small ubiquitin like modifier 1
  sterol regulatory element binding transcription factor 1
  TATA-box binding protein
  tripartite motif containing 25
  tumor protein p53
  tumor protein p63
  ubiquitin conjugating enzyme E2 I
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing transcription regulator 1
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.