BMP7, bone morphogenetic protein 7

BMP7, bone morphogenetic protein 7

• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

• Gene Synonyms (bone morphogenetic protein 7, osteogenic protein 1, OP-1,)
• NCBI Gene ID: 655
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18075
  UNIPROT ID#>>A8K571
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bone morphogenetic protein 7 interacts with:

• bone morphogenetic protein 7
  bone morphogenetic protein receptor type 1A
  bone morphogenetic protein receptor type 1B
  bone morphogenetic protein receptor type 2
  brain enriched guanylate kinase associated
  BTB domain containing 1
  chordin like 2
  ciliogenesis associated kinase 1
  coiled-coil domain containing 125
  contactin associated protein family member 3B
  cysteine rich tail 1
  dickkopf like acrosomal protein 1
  endoglin
  forkhead box N2
  G protein subunit beta 2
  glutathione S-transferase C-terminal domain containing
  growth differentiation factor 11
  growth differentiation factor 7
  immunoglobulin superfamily containing leucine rich repeat
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 3-1
  keratin associated protein 5-9
  keratin associated protein 9-8
  KH RNA binding domain containing, signal transduction associated 2
  microtubule associated scaffold protein 2
  N-acylethanolamine acid amidase
  NBPF member 19
  neuronal pentraxin 1
  noggin
  notch 2 N-terminal like A
  nuclear receptor coactivator 3
  olfactomedin 2
  olfactomedin 4
  PML nuclear body scaffold
  programmed cell death 10
  protein phosphatase 2 regulatory subunit B'delta
  protein tyrosine phosphatase receptor type K
  sclerostin domain containing 1
  serine/threonine kinase 26
  signaling lymphocytic activation molecule family member 1
  SMAD family member 1
  SMAD family member 3
  SMAD specific E3 ubiquitin protein ligase 1
  S-phase kinase associated protein 1
  STIP1 homology and U-box containing protein 1
  tafazzin
  teratocarcinoma-derived growth factor 1
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  tripartite motif containing 56
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3C
  ubiquitination factor E4A
  von Willebrand factor A domain containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.