ADAM11, ADAM metallopeptidase domain 11

ADAM11, ADAM metallopeptidase domain 11

• This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

• Gene Synonyms (MDC, disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, metalloproteinase-like, disintegrin-like, and cysteine-rich protein,)
• NCBI Gene ID: 4185
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DKD2
  UNIPROT ID#>>O75078
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADAM metallopeptidase domain 11 interacts with:

• cerebellin 4 precursor
  stanniocalcin 2
  tafazzin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.