APOH, apolipoprotein H

APOH, apolipoprotein H

• Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]

• Gene Synonyms (beta-2-glycoprotein 1, APC inhibitor, B2GPI, activated protein C-binding protein, anticardiolipin cofactor, apo-H, apolipoprotein H (beta-2-glycoprotein I), beta(2)GPI, epididymis secretory sperm binding protein, B2G1, B2GP1, BG,)
• NCBI Gene ID: 350
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P02749
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

apolipoprotein H interacts with:

• ATPase H+/K+ transporting subunit alpha
  cell division cycle 42
  coagulation factor X
  coagulation factor XII
  C-type lectin domain family 4 member G
  filamin A
  growth factor receptor bound protein 2
  GTP binding protein overexpressed in skeletal muscle
  LDL receptor related protein 2
  LDL receptor related protein 8
  lipoprotein(a)
  plasminogen
  RB binding protein 6, ubiquitin ligase
  tumor protein p53

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.