ICA1, islet cell autoantigen 1

ICA1, islet cell autoantigen 1

• This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

• Gene Synonyms (islet cell autoantigen 1, 69 kDa islet cell autoantigen, diabetes mellitus type I autoantigen, islet cell autoantigen 1 isoform, islet cell autoantigen 1, 69kDa, islet cell autoantigen p69, p69, testicular tissue protein Li 162, ICA69, ICAp69,)
• NCBI Gene ID: 3382
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RA29
  UNIPROT ID#>>Q05084
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

islet cell autoantigen 1 interacts with:

• coiled-coil domain containing 28A
  exocyst complex component 5
  inhibitor of growth family member 5
  keratin 33B
  McKusick-Kaufman syndrome
  methyl-CpG binding domain protein 3
  mortality factor 4 like 1
  protein interacting with PRKCA 1
  RAB2A, member RAS oncogene family
  RAB2B, member RAS oncogene family
  ring finger protein 123
  serine/threonine kinase 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.