HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

• The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

• Gene Synonyms (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, 3 beta-HSD type II, 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3-beta-HSD II, 3-beta-HSD adrenal and gonadal type, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, delta 5-delta 4-isomerase type II, progesterone reductase, short chain dehydrogenase/reductase family 11E, member 2, HSD3B, HSDB, SDR11E2,)
• NCBI Gene ID: 3284
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P26439
  UNIPROT ID#>>A0A024R0F9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 interacts with:

• asparaginyl-tRNA synthetase 1
  cathepsin F
  DEAD-box helicase 46
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  H2A clustered histone 11
  H3.2 histone (putative)
  KRAS proto-oncogene, GTPase
  leucine zipper and EF-hand containing transmembrane protein 1
  macroH2A.1 histone
  methylenetetrahydrofolate reductase
  pyruvate carboxylase
  transcription elongation factor A1
  transducin beta like 3
  transmembrane protein 38A
  VRK serine/threonine kinase 1
  WD repeat domain 36
  WW domain binding protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.