ANXA4, annexin A4

ANXA4, annexin A4

• Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

• Gene Synonyms (annexin A4, 35-beta calcimedin, annexin IV (placental anticoagulant protein II), annexin-4, carbohydrate-binding protein p33/p41, chromobindin-4, endonexin I, epididymis secretory protein Li 274, lipocortin IV, placental anticoagulant protein II, proliferation-inducing gene 28, proliferation-inducing protein 28, protein II, ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36,)
• NCBI Gene ID: 307
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6LES2
  UNIPROT ID#>>Q6P452
  UNIPROT ID#>>P09525
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

annexin A4 interacts with:

• annexin A7
  anterior gradient 2, protein disulphide isomerase family member
  cadherin 1
  cyclin-dependent kinase 1
  DnaJ heat shock protein family (Hsp40) member B11
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  glycoprotein 2
  H2A.X variant histone
  heterogeneous nuclear ribonucleoprotein L
  mercaptopyruvate sulfurtransferase
  NHL repeat containing 2
  N-myristoyltransferase 2
  nuclear factor kappa B subunit 1
  peptidyl arginine deiminase 4
  protection of telomeres 1
  RAB11 family interacting protein 5
  RAB8A, member RAS oncogene family
  ras homolog family member U
  sphingomyelin phosphodiesterase 1
  splicing factor 3a subunit 3
  TERF1 interacting nuclear factor 2
  TRAF family member associated NFKB activator
  ubiquitin C-terminal hydrolase L5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.