ABCD2, ATP binding cassette subfamily D member 2

ABCD2, ATP binding cassette subfamily D member 2

• The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ATP-binding cassette sub-family D member 2, ATP-binding cassette, sub-family D (ALD), member 2, adrenoleukodystrophy-like 1, adrenoleukodystrophy-related protein, ABC39, ALDL1, ALDR, ALDRP, hALDR,)
• NCBI Gene ID: 225
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBJ2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATP binding cassette subfamily D member 2 interacts with:

• ATP binding cassette subfamily D member 2
  ATP binding cassette subfamily D member 3
  neurotrophic receptor tyrosine kinase 1
  peroxisomal biogenesis factor 19

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.