AK2, adenylate kinase 2

AK2, adenylate kinase 2

• Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

• Gene Synonyms (adenylate kinase 2, mitochondrial, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, adenylate kinase isoenzyme 2, mitochondrial, adenylate monophosphate kinase, testis secretory sperm-binding protein Li 220n, ADK2,)
• NCBI Gene ID: 204
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P54819
  UNIPROT ID#>>F8VY04
  UNIPROT ID#>>F8W1A4
  UNIPROT ID#>>A0A140VK93
  UNIPROT ID#>>G3V213
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adenylate kinase 2 interacts with:

• abhydrolase domain containing 11
  acetyl-CoA acyltransferase 2
  adenylate kinase 3
  adenylate kinase 4
  AFG3 like matrix AAA peptidase subunit 2
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 1
  apoptosis-inducing factor, mitochondrion-associated 1
  ATP binding cassette subfamily C member 5
  ATP binding cassette subfamily C member 6
  ATP binding cassette subfamily E member 1
  BAG cochaperone 3
  BCL6 corepressor
  cathepsin B
  centrosomal protein 290
  crystallin zeta
  cullin 3
  cysteine rich protein 1
  cytochrome c oxidase assembly factor 4 homolog
  cytochrome c oxidase assembly factor COX14
  cytochrome c oxidase copper chaperone COX17
  deoxyuridine triphosphatase
  desmoplakin
  dihydrolipoamide dehydrogenase
  electron transfer flavoprotein subunit alpha
  electron transfer flavoprotein subunit beta
  elongation factor Tu GTP binding domain containing 2
  fascin actin-bundling protein 1
  fatty acid binding protein 3
  frataxin
  fumarylacetoacetate hydrolase domain containing 1
  GABA type A receptor associated protein like 2
  glutaredoxin 5
  GTPase, IMAP family member 8
  guanylate kinase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 6
  isocitrate dehydrogenase (NADP(+)) 1
  lactamase beta 2
  leucine rich repeat kinase 2
  methionine sulfoxide reductase B2
  methionine sulfoxide reductase B3
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  methylphosphate capping enzyme
  microtubule associated protein tau
  mitochondrial ribosomal protein L12
  mitochondrial ribosomal protein S7
  MX dynamin like GTPase 2
  myotrophin
  neurotrophic receptor tyrosine kinase 1
  nitrilase family member 2
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  nuclear receptor interacting protein 3
  nudix hydrolase 19
  peptidyl-tRNA hydrolase domain containing 1
  peroxiredoxin 5
  plasminogen receptor with a C-terminal lysine
  prosaposin
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  pyruvate kinase M1/2
  receptor for activated C kinase 1
  receptor interacting serine/threonine kinase 4
  ribonucleoprotein, PTB binding 1
  scaffold attachment factor B
  SET binding factor 2
  sex hormone binding globulin
  SH3 domain binding glutamate rich protein like
  SH3 domain binding glutamate rich protein like 3
  sideroflexin 1
  sigma non-opioid intracellular receptor 1
  sulfatase modifying factor 2
  superoxide dismutase 1
  synthesis of cytochrome C oxidase 1
  telomere maintenance 2
  thioredoxin
  thioredoxin 2
  thioredoxin domain containing 12
  TNF receptor associated protein 1
  TOX high mobility group box family member 4
  transketolase
  transmembrane protein 205
  treacle ribosome biogenesis factor 1
  Tu translation elongation factor, mitochondrial
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.