DEFB1, defensin beta 1

DEFB1, defensin beta 1

• Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (beta-defensin 1, BD-1, BD1, DEFB-1, DEFB101, HBD1,)
• NCBI Gene ID: 1672
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P60022
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

defensin beta 1 interacts with:

• family with sequence similarity 172 member A
  F-box and WD repeat domain containing 5
  huntingtin associated protein 1
  insulin degrading enzyme
  mitogen-activated protein kinase kinase kinase kinase 2
  N-myristoyltransferase 1
  N-myristoyltransferase 2
  peptidase M20 domain containing 2
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  replication timing regulatory factor 1
  vimentin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.