CYP2C8, cytochrome P450 family 2 subfamily C member 8

CYP2C8, cytochrome P450 family 2 subfamily C member 8

• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (cytochrome P450 2C8, P450 form 1, cytochrome P450 IIC2, cytochrome P450 MP-12, cytochrome P450 MP-20, cytochrome P450 form 1, cytochrome P450, family 2, subfamily C, polypeptide 8, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8, flavoprotein-linked monooxygenase, microsomal monooxygenase, s-mephenytoin 4-hydroxylase, xenobiotic monooxygenase, CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20,)
• NCBI Gene ID: 1558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z1F5
  UNIPROT ID#>>P10632
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome P450 family 2 subfamily C member 8 interacts with:

• cytochrome P450 family 2 subfamily C member 8
  DnaJ heat shock protein family (Hsp40) member B1
  ECSIT signaling integrator
  exocyst complex component 6
  interferon induced protein with tetratricopeptide repeats 3
  lon peptidase 1, mitochondrial
  microtubule associated serine/threonine kinase 1
  presenilin 1
  progesterone receptor membrane component 1
  Ras and Rab interactor 3
  ring finger protein 32

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.