COMP, cartilage oligomeric matrix protein

COMP, cartilage oligomeric matrix protein

• The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]

• Gene Synonyms (cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple), pseudoachondroplasia (epiphyseal dysplasia 1, multiple), thrombospondin-5, EDM1, EPD1, MED, PSACH, THBS5, TSP5,)
• NCBI Gene ID: 1311
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49747
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cartilage oligomeric matrix protein interacts with:

• cysteine rich tail 1
  fibronectin 1
  mesenchyme homeobox 2
  nuclear FMR1 interacting protein 2
  orthodenticle homeobox 1
  small glutamine rich tetratricopeptide repeat containing beta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.