CLNS1A, chloride nucleotide-sensitive channel 1A

CLNS1A, chloride nucleotide-sensitive channel 1A

• This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

• Gene Synonyms (methylosome subunit pICln, chloride channel regulatory protein, chloride channel, nucleotide sensitive 1A, chloride conductance regulatory protein ICln, chloride ion current inducer protein, i(Cln), reticulocyte pICln, reticulocyte protein ICln, CLCI, CLNS1B, ICln,)
• NCBI Gene ID: 1207
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9PJF4
  UNIPROT ID#>>J3KN38
  UNIPROT ID#>>P54105
  UNIPROT ID#>>E9PMI6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chloride nucleotide-sensitive channel 1A interacts with:

• alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  argonaute RISC catalytic component 3
  casein kinase 2 alpha 1
  cereblon
  CTP synthase 1
  CYLD lysine 63 deubiquitinase
  dimethylarginine dimethylaminohydrolase 2
  dual specificity phosphatase 5
  erythrocyte membrane protein band 4.1
  erythrocyte membrane protein band 4.1 like 2
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 4A2
  eukaryotic translation initiation factor 4A3
  F-box protein 6
  FERM domain containing 7
  FERM, ARH/RhoGEF and pleckstrin domain protein 2
  fibronectin 1
  fibulin 7
  G3BP stress granule assembly factor 1
  galectin 1
  galectin 3
  GAR1 ribonucleoprotein
  heat shock protein family A (Hsp70) member 5
  inorganic pyrophosphatase 1
  integrin subunit alpha 2b
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  LIM domain containing preferred translocation partner in lipoma
  LSM10, U7 small nuclear RNA associated
  LSM11, U7 small nuclear RNA associated
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  macrophage migration inhibitory factor
  mago homolog, exon junction complex subunit
  malate dehydrogenase 2
  methylphosphate capping enzyme
  NEDD8 ubiquitin like modifier
  neurotrophic receptor tyrosine kinase 1
  nitric oxide synthase 2
  N-myc downstream regulated 1
  osteoclast stimulating factor 1
  parathymosin
  PDZ and LIM domain 1
  perilipin 3
  phosphoglycerate mutase 1
  pirin
  plastin 3
  poly(A) specific ribonuclease subunit PAN2
  prefoldin subunit 2
  programmed cell death 10
  prolyl 4-hydroxylase subunit beta
  proteasome 20S subunit alpha 5
  protein arginine methyltransferase 5
  protein arginine N-methyltransferase 5
  protein disulfide isomerase family A member 6
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 4 regulatory subunit 2
  protein tyrosine phosphatase 4A2
  protein tyrosine phosphatase non-receptor type 3
  protein tyrosine phosphatase receptor type G
  pumilio RNA binding family member 1
  Rac family small GTPase 1
  RAD23 homolog A, nucleotide excision repair protein
  RecQ like helicase 4
  ribosomal protein L15
  ribosomal protein S2
  ribosomal protein S21
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  RIO kinase 1
  RNA binding fox-1 homolog 2
  S100 calcium binding protein A6
  SEC24 homolog A, COPII coat complex component
  SEC24 homolog C, COPII coat complex component
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein polypeptide E
  small nuclear ribonucleoprotein polypeptide F
  small nuclear ribonucleoprotein polypeptide G
  small nuclear ribonucleoprotein polypeptide N
  small nuclear ribonucleoprotein polypeptides B and B1
  snail family transcriptional repressor 1
  sorting nexin 12
  survival motor neuron 1
  thyroid hormone receptor interactor 6
  TPD52 like 2
  transforming growth factor beta 1
  transmembrane protein 17
  tripartite motif containing 14
  tripartite motif containing 25
  tRNA nucleotidyl transferase 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquilin 1
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin like 4A
  ubiquitin like modifier activating enzyme 2
  ubiquitin specific peptidase 5
  ubiquitin-fold modifier conjugating enzyme 1
  UBX domain protein 1
  VHL binding protein 1
  vir like m6A methyltransferase associated
  VRK serine/threonine kinase 3
  WD repeat domain 45
  WD repeat domain 77
  widely-interspaced zinc finger motifs

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.