SF3A2, splicing factor 3a subunit 2

SF3A2, splicing factor 3a subunit 2

• This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

• Gene Synonyms (splicing factor 3A subunit 2, SAP 62, pre-mRNA splicing factor SF3A, subunit 2, spliceosome associated protein 62, splicing factor 3a, subunit 2, 66kD, splicing factor 3a, subunit 2, 66kDa, PRP11, PRPF11, SAP62, SF3a66,)
• NCBI Gene ID: 8175
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q05DF2
  UNIPROT ID#>>Q15428
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

splicing factor 3a subunit 2 interacts with:

• angiogenic factor with G-patch and FHA domains 1
  apoptosis inhibitor 5
  apoptotic chromatin condensation inducer 1
  aquarius intron-binding spliceosomal factor
  arginine and glutamate rich 1
  BAR/IMD domain containing adaptor protein 2
  BCAS2 pre-mRNA processing factor
  BEN domain containing 2
  BUB3 mitotic checkpoint protein
  BUD31 homolog
  calcium homeostasis endoplasmic reticulum protein
  catenin beta like 1
  CD2 cytoplasmic tail binding protein 2
  cell cycle and apoptosis regulator 2
  cell division cycle and apoptosis regulator 1
  cilia and flagella associated protein 20
  coiled-coil domain containing 97
  cullin 3
  cullin 7
  CWC15 spliceosome associated protein homolog
  DEAD-box helicase 17
  DEAD-box helicase 23
  DEAD-box helicase 42
  DEAD-box helicase 46
  DnaJ heat shock protein family (Hsp40) member C8
  elongation factor Tu GTP binding domain containing 2
  ER membrane protein complex subunit 2
  eukaryotic translation initiation factor 4 gamma 3
  H3 clustered histone 6
  H4 clustered histone 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  high mobility group 20B
  HIV-1 Tat specific factor 1
  ISG15 ubiquitin like modifier
  ISY1 splicing factor homolog
  ISY1-RAB43 readthrough
  La ribonucleoprotein 7, transcriptional regulator
  lin-54 DREAM MuvB core complex component
  MUS81 structure-specific endonuclease subunit
  N(alpha)-acetyltransferase 10, NatA catalytic subunit
  NCK adaptor protein 2
  NIPBL cohesin loading factor
  NKAP domain containing 1
  nuclear cap binding protein subunit 2
  nuclear receptor interacting protein 2
  obscurin like cytoskeletal adaptor 1
  osteoclast stimulating factor 1
  peptidylprolyl isomerase E
  PHD finger protein 5A
  phosphatidylinositol glycan anchor biosynthesis class S
  poly(A) binding protein cytoplasmic 4
  poly(A) specific ribonuclease subunit PAN2
  poly(U) binding splicing factor 60
  polyglutamine binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  pyrin and HIN domain family member 1
  quinolinate phosphoribosyltransferase
  resistin
  ribonucleic acid export 1
  RNA binding motif protein 10
  RNA binding motif protein 17
  RNA binding motif protein 39
  RNA binding motif protein 5
  RNA binding motif protein X-linked
  RNA binding protein with serine rich domain 1
  SAP30 binding protein
  SEC31 homolog B, COPII coat complex component
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 9
  serine/arginine repetitive matrix 2
  serrate, RNA effector molecule
  SH3 domain containing ring finger 1
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein U5 subunit 200
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3a, subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 4
  splicing factor 3b subunit 5
  splicing factor 3b subunit 6
  structural maintenance of chromosomes 1A
  SURP and G-patch domain containing 1
  survival motor neuron domain containing 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  telomerase RNA component interacting RNase
  thyroid hormone receptor interactor 10
  TNF receptor associated protein 1
  trafficking from ER to golgi regulator
  transcription elongation regulator 1
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquitin specific peptidase 45
  WW domain binding protein 11
  WW domain binding protein 4
  WW domain containing oxidoreductase
  zinc finger CCCH-type containing 18
  zinc finger protein 830

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