DENND1B, DENN domain containing 1B

DENND1B, DENN domain containing 1B

• Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

• Gene Synonyms (DENN domain-containing protein 1B, DENN/MADD domain containing 1B, connecdenn 2, family with sequence similarity 31, member B, C1ORF18, C1orf218, FAM31B,)
• NCBI Gene ID: 163486
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R987
  UNIPROT ID#>>Q6P3S1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DENN domain containing 1B interacts with:

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