Ready-to-Use CRISPR Knock-In Reporter Cell Lines
HiBiT CRISPR knock-in cell lines bring the advantages of endogenous tagging directly to your bench. Each line is engineered with a tiny HiBiT tag integrated at the genomic locus of your target, allowing you to study protein abundance, localization, and activity in live cells — without artifacts from overexpression or variability from antibodies.
Our growing catalog includes HiBiT-, NanoLuc®, and HaloTag® knock-in pools and clones across a wide range of popular drug targets. Both N- and C-terminal fusions are available, and cell backgrounds are selected to match common workhorse lines or the biology most relevant to your research. Whether you need to measure receptor trafficking, signaling pathways, or targeted protein degradation, our validated models give you a fast, reliable starting point.
New to Knock-in Tagging? Learn about the benefits of endogenous tagging and options for getting started.
Cell Line Pools and Clones
We offer a large selection of pre-built CRISPR knock-in cell lines, ready to ship in 1-3 weeks. The tags used in these cell lines include HiBiT, NanoLuc®, and HiBiT-HaloTag® tandem tags. Cell backgrounds including LgBiT allow for live cell kinetic analysis of the HiBiT-tagged protein. Alternatively, LgBiT can be expressed using the ViaScript® LgBiT mRNA Delivery System to create live-cell assays.
Our licenses give our clients pass-through rights. Clients need not obtain CRISPR licenses on their own to use our pools and cell lines.
| Target | Tag | Terminus | Background | Clone/Pool | Request Details |
|---|---|---|---|---|---|
| ADAR1(p150) | HiBiT | N | A549 | C | |
| AKT1 | HiBiT | C | PC-3 | C | |
| APEX | HiBiT | C | HEK293 (LgBiT) | P | |
| AR | HiBiT | C | 22Rv1 | C | |
| AR | HiBiT | C | LNCaP clone FGC | C | |
| AR(V7) | HiBiT | C | 22Rv1 | C | |
| ARAF | HiBiT | N | A549 | C | |
| ARID1A | HiBiT | N | ES-2 | P | |
| ARID1A | HiBiT | C | ES-2 | P | |
| ARID1B | HiBiT | N | TOV-21G | P | |
| ARID1B | HiBiT | C | TOV-21G | P | |
| AURKA | HiBiT | C | MOLT-4 | P | |
| AURKA | HiBiT | C | PC-3 | P | |
| BCL10 | HiBiT | C | NCI-H1299 | C | |
| BCL11A | HiBiT | C | HEK293 (LgBiT) | C | |
| BCL11A | HiBiT | N | HEK293 (LgBiT) | C | |
| BCL2L1 | HiBiT | N | A549 | C | |
| BPTF | HiBiT | N | HEK293 | P | |
| BPTF | HiBiT | C | HEK293 | P | |
| BRAF | HiBiT | N | A549 | C/P | |
| BRAF(V600E) | HiBiT | N | A375 | C | |
| BRD2 | HiBiT | N | HEK293 (LgBiT) | C | |
| BRD3 | HiBiT | N | HEK293 (LgBiT) | C | |
| BRD4 | HiBiT | N | A549 | C | |
| BRD4 | HiBiT | N | HEK293 | C | |
| BRD4 | NanoLuc | N | HEK293 | C | |
| BRD4 | HiBiT | N | HEK293 (LgBiT) | C | |
| BRD4 | HiBiT-HaloTag | N | HEK293 (LgBiT) | C | |
| BRD4 | HiBiT | N | PC-3 | P | |
| BRD4 (CRBN KO) | HiBiT | N | HEK293 (LgBiT) | C | |
| BRD4 (VHL KO) | HiBiT | N | HEK293 (LgBiT) | C | |
| BRD7 | HiBiT | C | HEK293 | P | |
| BRD7 | HiBiT | C | HEK293 (LgBiT) | C | |
| BRD7 | HiBiT | N | HEK293 (LgBiT) | C/P | |
| BRD9 | HiBiT | C | HEK293 | P | |
| BRD9 | HiBiT | C | HEK293 (LgBiT) | C | |
| BRD9 | HiBiT | N | HEK293 (LgBiT) | C/P | |
| BRPF1 | HiBiT | N | HEK293 | P | |
| BRPF1 | HiBiT | C | HEK293 | P | |
| BTK | HiBiT | C | K562 | C | |
| BTK | HiBiT | C | Ramos | C | |
| CBLB | HiBiT | C | Jurkat | C/P | |
| CCNE1 | HiBiT | C | HEK293 | C | |
| CCNE1 | HiBiT | C | NIH:OVCAR-3 | C | |
| CCNK | HiBiT | N | A549 | C | |
| CDK1 | HiBiT | C | HEK293 | C | |
| CDK12 | HiBiT | C | A549 | C | |
| CDK2 | NanoLuc | C | HEK293 | C | |
| CDK2 | HiBiT | C | HEK293 | C | |
| CDK4 | HiBiT | C | HEK293 | P | |
| CDK4 | HiBiT | N | K562 | P | |
| CDK4 | NanoLuc | N | K562 | C | |
| CDK4 | NanoLuc | N | T-47D | C | |
| CDK6 | HiBiT | C | HEK293 | C | |
| CDK6 | HiBiT | C | K562 | P | |
| CDK6 | NanoLuc | N | K562 | C | |
| CDK7 | HiBiT | N | HEK293 | C | |
| CDK9 | HiBiT | N | HEK293 | C | |
| CDK9 | HiBiT | C | HEK293 | P | |
| CREBBP | HiBiT | C | NCI-H929 | P | |
| CREBBP | HiBiT | C | HEK293 | P | |
| CREBBP | HiBiT | N | HEK293 | P | |
| CREBBP | HiBiT | C | U-2 OS | C/P | |
| CSNK1A1 | HiBiT | C | HEK293 (LgBiT) | C/P | |
| CTNNB1 | HiBiT | C | DLD-1 | C | |
| CTNNB1 | HiBiT | N | HEK293 (LgBiT) | C | |
| CTNNB1 | HiBiT-HaloTag | C | HEK293 (LgBiT) | C | |
| CYC1 | HiBiT | C | BT-549 | C | |
| DDX3X | HiBiT | N | HEK293 (LgBiT) | C | |
| deltaN-TP63 | HiBiT | N | BxPC-3 | C | |
| DGKA (alpha) | HiBiT | N | Jurkat | C | |
| DGKB (beta) | HiBiT | N | A204 | C | |
| DGKZ (zeta) | HiBiT | N | Jurkat | C | |
| DPP9 | HiBiT | C | HEK293 (LgBiT) | C | |
| EGFR | HiBiT | C | A549 (LgBiT) | C | |
| EGFR | HiBiT | N | HeLa | C | |
| EP300 | HiBiT | C | NCI-H929 | P | |
| EP300 | HiBiT | C | HEK293 | P | |
| EP300 | HiBiT | N | HEK293 | P | |
| EP300 | HiBiT | C | U-2 OS | C/P | |
| ERBB3 (HER3) | NanoLuc | C | AU565 | C | |
| ESR1 (ER) | HiBiT | C | MCF7 | C | |
| EZH2 | HiBiT | C | HEK293 | C | |
| FANCM | HiBiT | C | HEK293 (LgBiT) | P | |
| FANCM | HiBiT | N | HEK293 (LgBiT) | P | |
| FANCM | HiBiT | N | U-2 OS | C/P | |
| FANCM | HiBiT | C | U-2 OS | C/P | |
| FGFR1 | HiBiT | C | A549 | C | |
| FGFR1 | HiBiT | C | NCI-H1299 | C | |
| FOXA1 | HiBiT | N | 22Rv1 | C | |
| GAPDH | HiBiT | C | HEK293 | C/P | |
| GSPT1 | HiBiT | N | HEK293 (LgBiT) | C/P | |
| HDAC6 | HiBiT | C | HeLa (LgBiT) | C | |
| HMOX1 | HiBiT | N | A549 | C | |
| HRI (EIF2AK1) | HiBiT | C | HEK293 | C | |
| HRI (EIF2AK1) | HiBiT | C | K562 | C | |
| IKZF1 (Ikaros) | HiBiT | C | Jurkat (LgBiT) | C/P | |
| IKZF2 (Helios) | HiBiT | C | Jurkat (LgBiT) | P | |
| IKZF2 (Helios) | HiBiT | N | Jurkat (LgBiT) | C/P | |
| IKZF3 (Aiolos) | HiBiT | N | MM.1S | C/P | |
| IL17RA | HiBiT | C | HeLa | P | |
| IL2 (CD38 KO) | NanoLuc | C | Jurkat | C | |
| IL4R | HiBiT | C | THP-1 | P | |
| IRAK1 | NanoLuc | N | Jurkat | C | |
| IRAK1 | HiBiT | C | NCI-H1299 | C | |
| IRAK1 | NanoLuc | N | THP-1 | C | |
| IRAK3 | NanoLuc | N | THP-1 | C | |
| IRAK4 | HiBiT | C | HeLa | C | |
| IRAK4 | HiBiT | C | K562 (LgBiT) | C | |
| IRAK4 | HiBiT | C | NCI-H1299 | C | |
| IRF5 | HiBiT | N | THP-1 | C | |
| IRF7 | HiBiT | N | THP-1 | C | |
| JAK1 | NanoLuc | C | HEK293 | C | |
| JAK2 | NanoLuc | C | TF-1 | C | |
| JAK2(V617F) | HiBiT | C | Hel 92.1.7 | C | |
| JAK2(V617F) | NanoLuc | C | Hel 92.1.7 | C | |
| KAT6A | HiBiT | N | T-47D | C | |
| KDM2A | HiBiT | N | U-2 OS | P | |
| KDM2A | HiBiT | N | HEK293 (LgBiT) | P | |
| KLK3 | HiBiT | C | 22Rv1 | C | |
| KRAS (G12C) | HiBiT | N | MIA PaCa-2 | C | |
| KRAS(G12D) | HiBiT | N | AsPC-1 | C | |
| KRAS(G12D) | HiBiT | N | HEK293 | C | |
| KRAS(G12D) | HiBiT | N | PANC-1 | C | |
| KRAS(G12D) | HiBiT | N | SW 1990 | C | |
| KRAS(G12S) | HiBiT | N | A549 | C | |
| KRAS(G12V) | HiBiT | N | SW620 | C | |
| KRAS(G12V) | HiBiT | N | HEK293 | C | |
| KRAS(G13D) | HiBiT | N | NCI-H647 | C | |
| KRAS(WT) | HiBiT | N | HEK293 | C | |
| KRAS(WT) | HiBiT | N | NCI-H1299 | C | |
| LIG1 | HiBiT | C | SK-OV-3 | P | |
| MAP2K1 | HiBiT | N | NCI-H1299 | C | |
| MAP3K7 | HiBiT-HaloTag | N | THP-1 | C | |
| MAP3K7 | HiBiT-HaloTag | C | THP-1 | C | |
| MAP3K14 | HiBiT-HaloTag | C | HeLa | C | |
| MAP4K1 (HPK1) | NanoLuc | N | Jurkat | C | |
| MAP4K1 (HPK1) | HiBiT | N | Jurkat | C/P | |
| MAP4K1 (HPK1) | HiBiT-HaloTag | N | Jurkat | C | |
| MAPK14 | NanoLuc | C | HEK293 | C | |
| MAPT | HiBiT | N | IMR-32 | C | |
| MAPT (2N4R) | HiBiT | C | IMR-32 | C | |
| MARC1 | HiBiT-HaloTag | C | HEK293 | C | |
| MET | HiBiT | C | A549 | C | |
| MET | HiBiT | C | HeLa | C | |
| Myc (cMyc) | HiBiT | C | HEK293 (LgBiT) | C | |
| MYH3 | HiBiT | C | RD | C | |
| NFE2L2 (NRF2) | HiBiT | N | A549 | C/P | |
| NFE2L2 (NRF2) | HiBiT | N | NCI-H460 | C | |
| NRAS(Q61R) | HiBiT | N | SW 1271 | C | |
| NRAS(WT) | HiBiT | N | HEK293 | C | |
| NTN4 (NETRIN-4) | HiBiT | C | DLD-1 | P | |
| PARP1 | HiBiT | C | HeLa | P | |
| PAX8 | HiBiT | N | NIH:OVCAR-3 | P | |
| PBRM1 | HiBiT | N | HEK293 (LgBiT) | C | |
| PBRM1 | HiBiT | C | HEK293 (LgBiT) | C | |
| PIK3CA | HiBiT | N | T-47D | C | |
| PIK3CA(E545K) | HiBiT | N | MCF7 | C | |
| PIK3CA(H1047R) | HiBiT | N | T-47D | C | |
| PIK3C3 | HiBiT | N | HEK293 (LgBiT) | C | |
| PKMYT1 | HiBiT | N | HEK293 (LgBiT) | P | |
| PKMYT1 | HiBiT | C | HEK293 (LgBiT) | P | |
| PLA2R1 | HiBiT | N | A431 | C | |
| PLK1 | HiBiT | N | A549 | P | |
| PLK4 | HiBiT | C | CHP-212 | C | |
| POLQ | HiBiT-HaloTag | C | DLD-1 | P | |
| POLQ | NanoLuc | C | DLD-1 | C/P | |
| POLQ | NanoLuc | N | DLD-1 | P | |
| PRMT5 | HiBiT | N | A549 | C | |
| PRMT5 | HiBiT | N | NCI-H1299 | C | |
| PTPN1 | HiBiT | N | Jurkat (LgBiT) | C | |
| PTPN2 | HiBiT | N | Jurkat (LgBiT) | C | |
| PTPN2 (isoform 2) | HiBiT | C | Jurkat (LgBiT) | C | |
| PTPN22 | HiBiT | N | Jurkat | C | |
| PTPN6 (SHP1) | HiBiT | C | THP-1 | C | |
| RAF1 (cRAF) | HiBiT | C | A549 | C/P | |
| RAF1 (cRAF) | HiBiT | C | Hs 766T | C | |
| RAF1 (cRAF) | HiBiT | C | Panc 08.13 | C | |
| RIPK1 | HiBiT | N | A375 | C | |
| RIPK1 | HiBiT | C | A375 | C | |
| RIPK2 | HiBiT | C | THP-1 | C | |
| RUBCN | HiBiT | N | HEK293 | C | |
| RUBCN | HiBiT | C | HEK293 (LgBiT) | C | |
| SALL4 | HiBiT | N | SK-N-DZ | C | |
| SETDB1 | HiBiT | C | A375 | C | |
| SETDB1 | HiBiT | N | A375 | C | |
| SKP2 | HiBiT | C | 22Rv1 | C | |
| SMAD2 | HiBiT-HaloTag | N | THP-1 | C | |
| SMAD3 | HiBiT | N | HeLa (LgBiT) | C | |
| SMAD3 | HiBiT-HaloTag | N | THP-1 | C | |
| SMARCA2 | HiBiT | C | HeLa | C/P | |
| SMARCA4 | HiBiT | C | HeLa | C/P | |
| SMARCA4 | HiBiT | C | HeLa (LgBiT) | P | |
| SOD2 | HiBiT-HaloTag | C | T-47D | C | |
| SPI1 | HiBiT-HaloTag | N | THP-1 | C | |
| STAT3 | HiBiT | C | HeLa (LgBiT) | C | |
| STAT3-beta | HiBiT | C | HeLa (LgBiT) | C | |
| STAT6 | HiBiT | C | Jurkat | P | |
| STAT6 | HiBiT | C | Jurkat (LgBiT) | C | |
| STC1 | HiBiT-HaloTag | C | A549 | C | |
| SUCLA2 | HiBiT | C | 22Rv1 | C | |
| α-Synuclein (SNCA) | HiBiT | C | HeLa | C | |
| TASL | HiBiT | C | THP-1 | C | |
| TEAD2 | HiBiT | N | HEK293 | C | |
| TNFRSF1A | HiBiT | C | HeLa | P | |
| TRIM63 | HiBiT | N | C2C12 | P | |
| TREM2 | HiBiT | N | THP-1 | C | |
| TREM2 | HiBiT | C | THP-1 | C | |
| TREM2 | HiBiT-HaloTag | C | THP-1 | C | |
| TYROBP (DAP12) | HiBiT | C | THP-1 | C | |
| TYROBP (DAP12) | HiBiT-HaloTag | C | THP-1 | C | |
| UBASH3A | HiBiT | C | Jurkat | P | |
| UBASH3A | HiBiT | N | Jurkat | C | |
| UBASH3B | HiBiT | C | Jurkat | C | |
| USP14 | HiBiT | C | HEK293 (LgBiT) | C/P | |
| USP14 | HiBiT | N | HEK293 (LgBiT) | P | |
| WRN | HiBiT | N | HCT116 | C | |
| WRN | HiBiT | C | HEK293 | C | |
| XBP1 | HiBiT | N | MCF7 | C | |
| XBP1s | HiBiT | C | MCF7 | C | |
| ZC3H12A | HiBiT | C | HeLa (LgBiT) | C | |
| ZC3H12A | HiBiT | C | Jurkat (LgBiT) | C | |
| ZC3H12A | HiBiT | N | Jurkat (LgBiT) | C |
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Ordering Options
Contact us to get started with the cell lines you need or to stay updated on our growing list of available knock-in cell lines.
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Build Your Own Cell Line & Custom Options
Not seeing the knock-in cell line you need? You have options. You can build your own by using our detailed protocols, NanoBiT® sequences and expert guidance to create tagged models directly in your lab. Or, if you’d prefer a ready-to-use solution, you can work with licensed service providers to create custom reporter knock-in cell lines.
Work with one of our licensed providers to integrate luminescent reporters into your target of interest. To find out more, view our partner websites:
EditCo Bio – Provides functionally validated CRISPR-edited cell lines, offering precise and scalable genome engineering solutions to support research in cell and gene therapy, drug discovery, and basic biology.
FUJIFILM CDI – Offers custom knock-in cell line generation using human iPSC-derived cells to create physiologically relevant models for disease research, drug discovery, and cell therapy development.
ALSTEM, Inc. – Delivers custom iPSCs, CRISPR/Cas9-edited cell lines, and viral vectors, supporting research in regenerative medicine, disease modeling, drug discovery, and basic biology.
We have a detailed protocol to help you design your own CRISPR-enabled workflow with HiBiT tagging.
After designing and ordering your guide RNA, donor DNA, and Cas9, be sure to obtain the rights to synthesize the HiBiT tag by filling out our licensing form.