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Promega Corporation

Maxwell® CSC: cGMP-Compliant Automated DNA Extraction from Blood

Cristopher Cowan is the Manager of the Integrated Solutions and Engineering group at Promega responsible for the development and integration of chemistries on robotic systems. He graduated from the University of Wisconsin-Madison with a bachelor's degree in Biochemistry and received a Ph.D. from the Molecular, Cellular and Developmental Biology department at the University of Colorado at Boulder. During this time he researched the role of Early Light Induced Proteins in plant development as well as a novel system for the overexpression and purification of membrane proteins in yeast. After completing his degree, Cristopher began working at Promega Corporation as a scientist in Technical Services where he became interested in robotics. Transferring to the Applications department he developed protocols for Promega's chemistries on a variety of automated platforms and collaborated with a number of automation companies. This work transitioned into his current role as Manager of the Integrated Solutions and Engineering department where he helps to determine the strategy and direction for Promega's automation efforts.

  • Cristopher Cowan, Ph.D.

  • Original Webinar Date: Tuesday, December 18, 2012


The United States FDA (Food and Drug Administration) has issued draft guidance stating that extraction systems for molecular diagnostic use must be designed and manufactured under cGMP, and labeled as Clinical Sample Concentrators (CSC). Promega Corporation is introducing the Maxwell® CSC instrument and the Maxwell® CSC Blood kit which have been designed and manufactured in compliance with this directive. In developing this instrument and chemistry, Promega has performed extensive evaluation of purification performance and consistency. The evaluation included analysis of genomic DNA yield and purity, consistency of instrument performance (multiple instrument, multiple day, multiple user), linearity of purification with input blood volume, concentration of eluate across elution volumes, and performance of eluted DNA in downstream assays. The Maxwell® CSC and Maxwell® CSC Blood kit show excellent consistency and performance in extracting genomic DNA from human whole blood. The Maxwell® CSC is manufactured in compliance with the FDA directives regarding Clinical Sample Concentrators and thus gives laboratories a compliant choice for genomic DNA purification from human whole blood samples. In this webinar we will present information regarding the Maxwell® CSC, the workflow for the clinical laboratory, and the performance of the Maxwell® CSC Blood Kit.

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