The AbTheneum™ antibody discovery platform from Single Cell Technology offers a rapid and convenient method to select candidates for testing therapeutic function. The output from AbTheneum™ is a database of cross-referenced data for each single cell. In this study, the most diverse set of antibodies were chosen for reconstruction and initial assays to pick the most promising leads. Cell-based functional assays serve as a practical first test to critically assess reconstructed antibodies. The massive output from antibody campaigns against BCMA, B7-H3, and TIGIT are presented and methods to select the most diverse subset of antibodies for reconstruction are discussed. All reconstructed antibodies were tested using cell-based functional assays to select for functional, high-affinity antibody candidates.
Chun-Nan Chen, PhD
Single Cell Technology, Inc.
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