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Molecular Diagnostics (MDx)
Tuesday, November 13, 2018
Kristin M. Riching
Despite the promising potential of PROTAC compounds in new drug discovery strategies, interrogating the multiple steps required to achieve effective PROTAC-mediated target protein degradation remains a challenge. This webinar will describe a platform of live-cell assays that can be used to measure real-time degradation kinetics and key cellular protein interactions mediating the degradation process. Join us to learn how these tools can be used to improve functional and cellular characterization of your PROTAC compounds.
Tuesday, November 06, 2018
Matthew Robers and Kelvin Lam
Methods for measuring kinase inhibitor potency in live cells are limited. In this webinar, we describe how the NanoBRET™ Target Engagement technique is overcoming technical limitations of existing methods by broadly enabling quantitative determination of kinase inhibitor occupancy in live cells. We also discuss a collaboration between Promega and Reaction Biology Corporation that has enabled conversion of these assays into a service compatible with high-throughput cell-based profiling.
Tuesday, October 23, 2018
Dan Lazar, PhD and Gary Allenby, PhD
Monitoring autophagy using imaging or western blotting methods can be cumbersome, low-throughput and subjective. Learn about a new LC3 reporter assay with three modalities (plate-reader based, imaging and blotting) to help scale up your autophagy analysis with confidence.
Tuesday, October 16, 2018
Chris Hosfield, PhD
While trypsin is the workhorse for bottom-up proteomics, it is not a magic bullet since tryptic digestion often leaves gaps in protein sequences. In this webinar Dr. Hosfield will describe the advantages of using a new recombinant Asp-N protease to fill in the gaps. He will also demonstrate how combining digests from multiple proteases can yield comprehensive sequence coverage of proteins from a single LC-MS/MS run.
Tuesday, September 11, 2018
Natascha Buter, MS and Joliene Lindholm, PhD
Do you have questions about PCR? Our Technical Support Scientists Natascha Buter and Joliene Lindholm will be answering all your questions about nucleic acid amplification. Learn more about endpoint PCR and how to make sure you have a successful run every time.