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Viafect Citations

ViaFect™ Transfection Reagent is gaining popularity due to it's high-performance, low-toxicity and utility across many different cell lines. The articles below represent a selection of 2017 and 2018 papers demonstrating use of ViaFect with a wide selection of cell types.

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Cell Line Citation
A549 Somensi, N., et al. (2017) Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells. Cell. Physiol. Biochem. 42, 2507-22.
AF22 Chai, M., et al. (2018) Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors. Genes Dev. 32, 165-80.
AGS Cerda-Opazo, P., et al. (2018) Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. Oncotarget 9, 12853-67.
AU565 Bagu, E.T., et al. (2017) Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget 8, 11442-59.
B16F0 Morita, T. and Hayashi, K. (2018) Tumor progression is mediated by thymosin-β4 through a TGFβ/MRTF signaling axis. Mol. Cancer Res. 16, 880-93.
B16F1 Morita, T. and Hayashi, K. (2018) Tumor progression is mediated by thymosin-β4 through a TGFβ/MRTF signaling axis. Mol. Cancer Res. 16, 880-93.
BJ1-7TGP Kramer, N., et al. (2017) Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression. Oncogene 36, 5460-72.
Bovine Aortic
Endothelial Cells
Gupta, R.M., et al. (2017) A genetic variant associated with five vascular diseases is a distal regulator of endothelin-1 gene expression. Cell 170, 522-33.
BT Alkheraif, A.A., et al. (2017) Type 2 BVDV Npro suppresses IFN-1 pathway signaling in bovine cells and augments BRSV replication. Virology 507, 123-34.
C2C12 Saklayen, N., et al. (2017) Analysis of poration-induced changes in cells from laser-activated plasmonic substrates. Biomed. Opt. Express 8, 4756-71.
CHO Hoonakker, M.E., et al. (2017) Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test. Vaccine 35, 1152-60.
COS-7 Nakagawa, T., et al. (2017) N-glycan-dependent cell-surface expression of the P2Y2 receptor and N-glycan-independent distribution to lipid rafts. Biochem. Biophys. Res. Comm. 485, 427-31.
COV-504 Lu, T., et al. (2018) Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis. Cancer Sci. 109, 2221-34.
EH-GB1 Ma, Q., et al. (2018) EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer Lett. 430, 97-108.
EH-GB1 Hao, J., et al. (2017) Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. Int. J. Oncol. 51, 823-32
GBC-SD Ma, Q., et al. (2018) EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer Lett. 430, 97-108.
GBC-SD Hao, J., et al. (2017) Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. Int. J. Oncol. 51, 823-33
GIST882 Wang, L., et al.(2017) Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway. Tumor Biol. 39, 1010428317691426.
H1299 Eriksson, M., et al. (2017) The effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Mol. Cell. Biol. 37, e00328-17.
H358 Motooka, Y., et al. (2017) Pathobiology of Notch2 in lung cancer. Pathology 49, 486-93.
H5 Mouse chondrocytes Kalev-Zylinska, M.L., et al. (2018) Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes. Osteoarthr. Cartilage https://doi.org/10.1016/j.joca.2018.06.015
H9c2 Mudaliar, H, et al. (2017) Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway. Int. J. Cardiol. 228, 729-41.
HCC Xu, S., et al. (2018) NFATc1 is a tumor suppressor in hepatocellular carcinoma and induces tumor cell apoptosis by activating the FasL-mediated extrinsic signaling pathway. Cancer Med. DOI: 10.1002/cam4.1716.
HCC1569 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
HCC70 Bagu, E.T., et al. (2017) Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget 8, 11442-59.
HCT 116 Kranz, P., et al. (2017) PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)Cell Death Dis. 8, e2986.
HCT 116 Lin, H., et al. (2017) DHX32 promotes angiogenesis in colorectal cancer through aumenting β-catenin signaling to induce expression of VEGFA. EBioMedicine 18, 62-72
HCT 116 Eriksson, M., et al. (2017) The effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Mol. Cell. Biol. 37, e00328-17.
HCT-8 Lin, H., et al. (2017) DHX32 promotes angiogenesis in colorectal cancer through aumenting β-catenin signaling to induce expression of VEGFA. EBioMedicine 18, 62-72
HEK 293 Higashioki, K., et al. (2017) Mygenic differentiation from MYOGENIN-mutated human iPS cells by CRISPR/Cas9. Stem Cells Intl. 9210494.
HEK 293T Foxler, D.E., et al. (2018) A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia. EMBO Mol. Med. 10, e8304
HEK 293T Zhang, Y., et al. (2017) Rescue of Pink1 deficiency by stress-dependent activation of autophagy. Cell Chem. Biol. 24, 471-80.
HEK 293T Cerda-Opazo, P., et al. (2018) Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. Oncotarget 9, 12853-67.
HeLa Monson, E.A., et al. (2018) Lipid droplet density alters the early innate immune response to viral infection. PLoS One 13, e0190597.
HeLa Foxler, D.E., et al. (2018) A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia. EMBO Mol. Med. 10, e8304.
HeLa Jeong, M., et al. (2017) USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability. Oncogene 36, 458-70.
HeLa Heschen, C.L., et al. (2017) NuMA recruits dynein activity to microtubule minus-ends at mitosis. eLife 6, e29328.
HepG2 Qi, Z., et al. (2017) Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. Biomed. Pharmacother. 88, 252-9
HepG2 Xu, H., et al. (2018) MicroRNA-122 supports robust innate immunity in hepatocytes by suppressing STAT3 phosphorylation. bioRχiv doi: http://dx.doi.org/10.1101/250748
HPNE Bruno, W., et al. (2017) Functional analysis of a CDKN2A 5'UTR germline variant associated with pancreatic cancer development. PLoS One 12, e0189123.
Hs578T Oh, S., et al.(2017) Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3β/β-catenin/survivin signaling pathway in breast cancer cells. Arch. Biochem. Biophys. 636, 110-22.
Hs578T Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
Hu5/KD3 Higashioki, K., et al. (2017) Mygenic differentiation from MYOGENIN-mutated human iPS cells by CRISPR/Cas9. Stem Cells Intl. 9210494
HuH-7 Monson, E.A., et al. (2018) Lipid droplet density alters the early innate immune response to viral infection. PLoS One 13, e0190597.
HuH-7 Xu, H., et al. (2018) MicroRNA-122 supports robust innate immunity in hepatocytes by suppressing STAT3 phosphorylation. bioRχiv doi: http://dx.doi.org/10.1101/250747
HuH-7.5 Eyre, N.S., et al. (2017) Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus NS5A protein into the extracellular environment. Virology 507, 20-31.
Human primary cumulus cells Qiao, G., et al. (2017) Deregulation of WNT2/FZD3/β-catenin pathway compromises the estrogen synthesis in cumulus cells from patients with polycystic ovary syndrome. Biochem. Biophys. Res. Comm. 493, 847-54.
Human foreskin fibroblasts Kalser, J., et al. (2017) Differences in growth properties among two human cytomegalovirus glycoprotein O genotypes. Front. Microbiol. 8, 1609.
Human podocytes Fan, Y., et al. (2017) Rtn1a-mediated endoplasmic reticulum stress in podocyte injury and diabetic nephropathy. Sci. Reports 7, 323.
Human pulmonary artery endothelial cells (HPAEC) Nakajima, H., et al. (2017) Flow-dependent endothelial YAP regulation contributes to vessel maintenance. Develop. Cell 40, 523-36.
Human small airway epithelial cells (SAEC)  Mao, P., et al. (2017) MicroRNA-19b mediates lung epithelial-mesenchymal transition via phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase in response to mechanical stretch. Am. J. Resp. Cell Mol. Biol. 56, 11-9.
Human synovial fluid-derived mesenchymal stem cells Liu, W., et al. (2017) IL-1β impedes the chondrogenic differentiation of synovial fluid mesenchymal stem cells in the human temporomandibular joint. Int. J. Mol. Med. 39, 317-26.
Human umbilical vein endothelial cells Wang, J., et al. (2017) NINJ2– A novel regulator of endothelial inflammation and activation. Cell Signal. 35, 231-41. 
ICC Zhu, X., et al. (2017) Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. Int. J. Mol. Med. 40, 1143-51.

iCell® cardiomyocytes

Hall, A.R., et al. (2018) Visualizing mutation-specific differences in the trafficking-deficient phenotype of Kv11.1 proteins linked to long QT syndrome type 2. Front. Physiol. 9, 284.
iCell® cardiomyocytes
Fenix, A.M., et al. (2017) Muscle specific stress fibers give rise to sarcomeres and are mechnistically distinct from stress fibers in non-muscle cell. bioRχiv doi: https://doi.org/10.1101/235424.
iCell® cardiomyocytes Taneja, N., et al. (2018) Focal adhesion kinase regulates early steps of myofibrillogenesis in cardiomyocytes. bioRχiv ; doi: http://dx.doi.org/10.1101/261248.
IGROV1 Alam, S., et al. (2017) Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells. Sci. Reports 7, 45367.
Induced hepatocyte-like cells (iHeps) Katayama, H., et al. (2017) Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon. Sci. Reports 7, 44498.
INS-1 Spohrer, S., et al. (2017) Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic β-cells. Sci. Reports 7, 16367
K562 Espadinha, A.-S., et al. (2017) A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells. Oncotarget 8, 76174-88.
MCF-10A Eriksson, M., et al. (2017) The effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Mol. Cell. Biol. 37, e00328-17.
MCF7 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
MDA-MB-231 Oh, S., et al. (2017) Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3β/β-catenin/survivin signaling pathway in breast cancer cells. Arch. Biochem. Biophys. 636, 110-22.
MDA-MB-231 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
MDA-MB-231 Eriksson, M., et al. (2017) The effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Mol. Cell. Biol. 37, e00328-17.
MDA-MB-435s Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
MDA-MB-436 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
MDA-MB-438 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
MIN6-K8 Zhang, W., et al. (2017) Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells. Biochem. Biophys. Res. Comm. 493, 677-83.
MIO-M1 Chu-Tan, J.A., et al. (2018) MicroRNA-124 dysregulation is associated with retinal inflammation and photoreceptor death in the degenerating retina. Invest. Ophthalmol. Vis. Sci. 59, 4094-105.
MOE Dean, M., Davis, D.A. and Burdette, J.E. (2017) Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 391, 114-24.
Mouse embryonic fibroblast Campostrini, G., et al. (2017) The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability. Cardiovasc. Res. 113, 1256-65.
Mouse Oligodendrocyte progenitor cells (mOPC) Weider, M., et al. (2018) Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat. Comm. 9, 899.
MRC4V1 Bertoletti, F., et al. (2017) Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle. Nucl. Acids Res. 45, 9441-54.
Murine neural stem cells Bansod, S., Kageyama, R., and Ohtsuka, T. (2017) Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development. Development 144, 3156-67.
Murine renal tubular epithelial cells Yuan, X., et al. (2017) Bone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223. Stem Cell Res. Ther. 8, 146
NCCIT Park, S.-W., et al. (2017) NANOG gene expression is regulated by the ETS transcription factor ETV4 in human embryonic carcinoma NCCIT cells. Biochem. Biophys. Res. Comm.487, 532-8.
NCI-N87 Cerda-Opazo, P., et al. (2018) Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. Oncotarget 9, 12853-67.
NIH 3T3 Bansod, S., Kageyama, R., and Ohtsuka, T. (2017) Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development. Development 144, 3156-67.
NIT-1 Lee, J.-J., et al. (2017) Calcium ion induced structural changes promote dimerization of scretagogin, which is required for its insulin secretory function. Sci. Reports 7, 6976.
NMuMG Morita, T. and Hayashi, K. (2018) Tumor progression is mediated by thymosin-β4 through a TGFβ/MRTF signaling axis. Mol. Cancer Res. 16, 880-93.
NOZ Ma, Q., et al. (2018) EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer Lett. 430, 97-108.
NOZ Hao, J., et al. (2017) Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. Int. J. Oncol. 51, 823-31
OCUG Ma, Q., et al. (2018) EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer Lett. 430, 97-108.
OCUG Hao, J., et al. (2017) Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. Int. J. Oncol. 51, 823-35
PANC1 Villarino, N., et al. (2017) A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer. Oncotarget 8, 53154-67.
PBMC Cai, F., et al. (2018) MicroRNA-146b-3p regulates the development and progression of cerebral infarction with diabetes through RAF1/P38MAPK/COX-2 signaling pathway. Am. J. Transl. Res. 10, 618-28.
PC3 Xu, H., et al. (2018) MicroRNA-122 supports robust innate immunity in hepatocytes by suppressing STAT3 phosphorylation. bioRχiv doi: http://dx.doi.org/10.1101/250746
PtK2 Long, A.F., Udy, D.B., and Dumont, S. (2017) Hec1 tail phosphorylation differentially regulates mammalian kinetochore coupling to polymerizing and depolymerizing microtubules. Curr. Biol. 27, 1692-9.
PtK2 Heschen, C.L., et al. (2017) NuMA recruits dynein activity to microtubule minus-ends at mitosis. eLife 6, e29328.
RAW264.7 Ricci, E., et al. (2017) Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression. FASEB J. 31, 3054-65.
RMC Gao, H.-Y. and Han, C.-X. (2017) The role of PTEN up-regulation in suppressing glomerular mesangial cells proliferation and nephritis pathogenesis. Eur. Rev. Med. Pharmacol. Sci. 21, 3634-41.
RPE1 Heschen, C.L., et al. (2017) NuMA recruits dynein activity to microtubule minus-ends at mitosis. eLife 6, e29328.
SaOS2 Nishita, M., et al. (2017) Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci. Reports 7, 1.
SGC-996 Ma, Q., et al. (2018) EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer Lett. 430, 97-108.
SGC-996 Hao, J., et al. (2017) Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. Int. J. Oncol. 51, 823-34
SH-SY5Y Zhang, Y., et al. (2017) Rescue of Pink1 deficiency by stress-dependent activation of autophagy. Cell Chem. Biol. 24, 471-80.
SK-BR-3 Onodera, Y., et al. (2018) Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat. Comm. 9, 2682.
SK-HEP-1 McDonald, C.J., et al. (2018) Evaluation of a bone morphogentic protein 6 variant as a cause of iron loading. Hum. Genom. 12, 23.
SKOV3 Yan, X.-Y., et al. (2017) p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-κB pathway in human ovarian cancer cells. Cancer Sci. 108, 1405-13.
SKOV3 Lu, T., et al. (2018) Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis. Cancer Sci. 109, 2221-34.
SKOV3 Alam, S., et al. (2017) Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells. Sci. Reports 7, 45367.
SNU-1 Cerda-Opazo, P., et al. (2018) Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. Oncotarget 9, 12853-67
SW480 Lin, H., et al. (2017) DHX32 promotes angiogenesis in colorectal cancer through aumenting β-catenin signaling to induce expression of VEGFA. EBioMedicine 18, 62-72
SW620 Lin, H., et al. (2017) DHX32 promotes angiogenesis in colorectal cancer through aumenting β-catenin signaling to induce expression of VEGFA. EBioMedicine 18, 62-72
THP-1 Wiśnik, E.,  Płoszaj, T. and Robaszkiewicz, A. (2017) Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes. Sci. Reports 7, 9483.
TT Jang, S., et al. (2017) Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo. Oncotarget 8, 70828-40.
U2OS Foxler, D.E., et al. (2018) A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia. EMBO Mol. Med. 10, e8304.
U2OS Nishita, M., et al. (2017) Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci. Reports 7, 1.
U373MG Kwon, R.-J., et al.(2017) Roles of zinc-fingers and homeoboxes 1 during the proliferation, migration, and invasion of glioblastoma cells. Tumor Biol39, 1010428317694575.
U87 Diplas, B.H., et al. (2018) The genomic landscape of TERT promoter wildtype-IDHwildtype glioblastoma. Nat. Comm. 9, 2087.
UACC-62 Jeong, M., et al. (2017) USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability. Oncogene 36, 458-70.
WI-38 Eriksson, M., et al. (2017) The effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Mol. Cell. Biol. 37, e00328-17.